LOCUS HUMMTCG 16569 bp DNA circular PRI 13-NOV-2001 DEFINITION Human mitochondrion, complete genome. ACCESSION J01415 M12548 M58503 M63932 M63933 VERSION J01415.1 GI:1944628 KEYWORDS 12S ribosomal RNA; 16S ribosomal RNA; ATPase; D-loop; circular; complete genome; cytochrome; cytochrome oxidase; displacement loop; oxidase; ribosomal RNA; transfer RNA; transfer RNA-Ala; transfer RNA-Arg; transfer RNA-Asn; transfer RNA-Asp; transfer RNA-Cys; transfer RNA-Gln; transfer RNA-Glu; transfer RNA-Gly; transfer RNA-His; transfer RNA-Ile; transfer RNA-Leu; transfer RNA-Lys; transfer RNA-Met; transfer RNA-Phe; transfer RNA-Pro; transfer RNA-Ser; transfer RNA-Thr; transfer RNA-Trp; transfer RNA-Tyr; transfer RNA-Val; unidentified reading frame. SOURCE mitochondrion Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 105 to 323) AUTHORS Crews,S., Ojala,D., Posakony,J., Nishiguchi,J. and Attardi,G. TITLE Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication JOURNAL Nature 277 (5693), 192-198 (1979) MEDLINE 81012010 PUBMED 551247 REFERENCE 2 (bases 1 to 16569) AUTHORS Anderson,S., Bankier,A.T., Barrell,B.G., de Bruijn,M.H.L., Coulson,A.R., Drouin,J., Eperon,I.C., Nierlich,D.P., Roe,B.A., Sanger,F., Schreier,P.H., Smith,A.J.H., Staden,R. and Young,I.G. TITLE Sequence and organization of the human mitochondrial genome JOURNAL Nature 290 (5806), 457-465 (1981) MEDLINE 81173052 PUBMED 7219534 REFERENCE 3 (bases 1 to 16569) AUTHORS Montoya,J., Ojala,D. and Attardi,G. TITLE Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs JOURNAL Nature 290 (5806), 465-470 (1981) MEDLINE 81173053 PUBMED 7219535 REFERENCE 4 (bases 16015 to 16214) AUTHORS Doda,J.N., Wright,C.T. and Clayton,D.A. TITLE Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78 (10), 6116-6120 (1981) MEDLINE 82082408 PUBMED 6273850 REFERENCE 5 (bases 1 to 16569) AUTHORS Attardi,G., Chomyn,A. and Mariottini,P. TITLE Genetic control of chloroplast and mitochondrial H+-ATPases JOURNAL (in) Papa,S., Altendorf,K., Ernster,L. and Packer,L. (Eds.); H+-ATPASE (ATP SYNTHASE): STRUCTURE, FUNCTION, BIOGENESIS. THE F0 F1 COMPLEX OF COUPLING MEMBRANES.: 25-40; Adriatica Editrice, Bari, Italy (1984) REFERENCE 6 (bases 324 to 743) AUTHORS Bogenhagen,D.F., Applegate,E.F. and Yoza,B.K. TITLE Identification of a promoter for transcription of the heavy strand of human mtDNA: in vitro transcription and deletion mutagenesis JOURNAL Cell 36 (4), 1105-1113 (1984) MEDLINE 84156530 PUBMED 6323020 REFERENCE 7 (bases 1 to 16569) AUTHORS Chomyn,A., Mariottini,P., Cleeter,M.W., Ragan,C.I., Matsuno-Yagi,A., Hatefi,Y., Doolittle,R.F. and Attardi,G. TITLE Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase JOURNAL Nature 314 (6012), 592-597 (1985) MEDLINE 85188293 PUBMED 3921850 REFERENCE 8 (bases 1 to 16569) AUTHORS Chomyn,A., Cleeter,M.W., Ragan,C.I., Riley,M., Doolittle,R.F. and Attardi,G. TITLE URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit JOURNAL Science 234 (4776), 614-618 (1986) MEDLINE 87018846 PUBMED 3764430 REFERENCE 9 (bases 15888 to 15954) AUTHORS Mita,S., Monnat,R.J. Jr. and Loeb,L.A. TITLE Direct selection of mutations in the human mitochondrial tRNAThr gene: reversion of an 'uncloneable' phenotype JOURNAL Mutat. Res. 199 (1), 183-190 (1988) MEDLINE 88202005 PUBMED 3362158 REFERENCE 10 (bases 1 to 16569) AUTHORS Johns,D.R. and Cornblath,D.R. TITLE Molecular insight into the asymmetric distribution of pathogenetic human mitochondrial DNA deletions JOURNAL Biochem. Biophys. Res. Commun. 174 (1), 244-250 (1991) MEDLINE 91113202 PUBMED 1989603 REFERENCE 11 (sites) AUTHORS Moraes,C.T., Andreetta,F., Bonilla,E., Shanske,S., DiMauro,S. and Schon,E.A. TITLE Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region JOURNAL Mol. Cell. Biol. 11 (3), 1631-1637 (1991) MEDLINE 91141513 PUBMED 1996112 REFERENCE 12 (sites) AUTHORS Rotig,A., Cormier,V., Koll,F., Mize,C.E., Saudubray,J.M., Veerman,A., Pearson,H.A. and Munnich,A. TITLE Site-specific deletions of the mitochondrial genome in the Pearson marrow-pancreas syndrome JOURNAL Genomics 10 (2), 502-504 (1991) MEDLINE 91301713 PUBMED 1712754 REFERENCE 13 (bases 1 to 16569) AUTHORS Kogelnik,A.M. TITLE Direct Submission JOURNAL Submitted (18-APR-1997) Center for Molecular Medicine, Emory University School of Medicine, 462 Clifton Road, Suite 420, Atlanta, GA 30322, USA REMARK sequence updated COMMENT On Apr 18, 1997 this sequence version replaced gi:337188. L-strand is shown. Numbered RNAs are polyadenylated, presumed messengers. Several termination codons utilize 'a' or 'aa' in poly-A tail [2]. Alternative termination codons are 'aga' and 'agg'. Alternative initiation codons are 'ata' and 'att'. The H-chain D-loop contains a 7S RNA, starting at base 191 leftward, which is approximately 680 bases long [2]. Complete source information: Human placenta mitochondrial DNA [2]; HeLa cells mtDNA [2],[1],[5]; HeLa cells mt mRNA [3]; KB cells mtDNA [4]. FEATURES Location/Qualifiers source 1..16569 /organism="Homo sapiens" /organelle="mitochondrion" /mol_type="genomic DNA" /db_xref="taxon:9606" /cell_line="HeLa; KB" /tissue_type="placenta" D-loop complement(join(16104..16569,1..191)) /note="origin H-strand replication" /citation=[4] rep_origin 1..191 /citation=[1] repeat_unit 471..478 /note="5' first direct repeat of the deletion junction." repeat_unit 480..483 /note="5' second direct repeat of the deletion junction." misc_signal 531..568 /note="H-strand transcription promoter" /citation=[6] misc_RNA <556..>556 /product="H-strand" /citation=[6] variation 573..4415 /note="3843 bp deletion causing external ophthalmoplegia" /citation=[11] /replace="" tRNA 577..647 /product="tRNA-Phe" /note="codon recognized: UUC; NAR: 1455" /anticodon=(pos:611..613,aa:Phe) rRNA 648..1601 /product="12S ribosomal RNA" tRNA 1602..1670 /product="tRNA-Val" /note="codon recognized: GUA; NAR: 2053" /anticodon=(pos:1633..1635,aa:Val) rRNA 1671..3229 /product="16S ribosomal RNA" tRNA 3230..3304 /product="tRNA-Leu" /note="NAR: 1054" mRNA 3305..4263 /product="RNA 13" CDS 3307..4263 /note="NADH dehydrogenase subunit 1" /citation=[7] /codon_start=1 /transl_table=2 /product="MTND1" /protein_id="AAB58943.1" /db_xref="GI:337189" /translation="MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYG LLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGL LFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSF NLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAG PFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTA YPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT" tRNA 4263..4331 /product="tRNA-Ile" /note="codon recognized: AUC; NAR: 0997" /anticodon=(pos:4292..4294,aa:Ile) tRNA complement(4329..4400) /product="tRNA-Gln" /note="NAR: 0597" /anticodon=(pos:4362..4364,aa:Gln) tRNA 4402..4469 /product="tRNA-Met" /note="codon recognized: AUG; NAR: 1297" /anticodon=(pos:4432..4434,aa:Met) mRNA 4470..5511 /product="RNA 12" CDS 4470..5511 /note="NADH dehydrogenase subunit 2; TAA stop codon is completed by the addition of 3' A residues to the mRNA" /citation=[7] /codon_start=1 /transl_except=(pos:5511,aa:TERM) /transl_table=2 /product="MTND2" /protein_id="AAB58944.1" /db_xref="GI:2052363" /translation="MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVL TKKMNPRSTEAAIKYFLTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAM AMKLGMAPFHFWVPEVTQGTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSIL SIMAGSWGGLNQTQLRKILAYSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLL LNLNSSTTTLLLSRTWNKLTWLTPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSL IIPTIMATITLLNLYFYLRLIYSTSITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTT LLLPISPFMLMIL" repeat_unit 5152..5159 /note="3' first direct repeat of the deletion junction." repeat_unit 5160..5163 /note="3' second direct repeat of the deletion junction." tRNA 5512..5579 /product="tRNA-Trp" /note="codon recognized: UGA; NAR: 1897" /anticodon=(pos:5544..5546,aa:Trp) tRNA complement(5587..5655) /product="tRNA-Ala" /note="NAR: 0097" /anticodon=(pos:5617..5619,aa:Ala) tRNA complement(5657..5729) /product="tRNA-Asn" /note="NAR: 0297" /anticodon=(pos:5690..5692,aa:Asn) rep_origin 5741..5752 /note="origin L-strand replication" tRNA complement(5761..5826) /product="tRNA-Cys" /note="NAR: 0497" /anticodon=(pos:5789..5791,aa:Cys) tRNA complement(5826..5891) /product="tRNA-Tyr" /note="NAR: 1997" /anticodon=(pos:5855..5857,aa:Tyr) mRNA 5901..7517 /product="RNA 9" CDS 5904..7445 /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit 1" /protein_id="AAB58945.1" /db_xref="GI:506829" /translation="MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQP GNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSF WLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILG AINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT FFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWA MMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKW SAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGG FIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTW NILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEP VYMKS" tRNA complement(7445..7516) /product="tRNA-Ser" /note="NAR: 1697" /anticodon=(pos:7477..7479,aa:Ser) tRNA 7518..7585 /product="tRNA-Asp" /note="codon recognized: GAC; NAR: 0397" /anticodon=(pos:7548..7550,aa:Asp) mRNA 7586..8294 /product="RNA 16" CDS 7586..8269 /codon_start=1 /transl_table=2 /product="cytochrome oxidase subunit 2" /protein_id="AAB58946.1" /db_xref="GI:337192" /translation="MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFL TLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGH QWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVL HSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKI FEMGPVFTL" tRNA 8295..8364 /product="tRNA-Lys" /note="codon recognized: AAA; NAR: 1197" /anticodon=(pos:8323..8325,aa:Lys) mRNA 8365..9207 /product="RNA 14" CDS 8366..8572 /note="putative" /citation=[5] /codon_start=1 /transl_table=2 /product="ATPase 8" /protein_id="AAB58947.1" /db_xref="GI:337193" /translation="MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKM KNYNKPWEPKWTKICSLHSLPPQS" variation 8470..13446 /note="deleted in Pearson marrow-pancreas syndrome" /citation=[12] /replace="" CDS 8527..9207 /codon_start=1 /transl_table=2 /product="ATPase 6" /protein_id="AAB58948.1" /db_xref="GI:2052364" /translation="MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLIT TQQWLIKLTSKQMMTMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNL AMAIPLWAGTVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRL TANITAGHLLMHLIGSATLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLV SLYLHDNT" mRNA 9207..9990 /product="RNA 15" CDS 9207..9987 /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:9987,aa:TERM) /transl_table=2 /product="cytochrome oxidase subunit 3" /protein_id="AAB58949.1" /db_xref="GI:2052365" /translation="MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLM LGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFY HSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMI QALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTIC FIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG" tRNA 9991..10058 /product="tRNA-Gly" /note="codon recognized: GGA; NAR: 0797" /anticodon=(pos:10021..10023,aa:Gly) variation 9996..15896 /note="deleted in Pearson marrow-pancreas syndrome" /citation=[12] /replace="" mRNA 10059..>10404 /product="RNA 17 mRNA" CDS 10059..10404 /note="NADH dehydrogenase subunit 3; TAA stop codon is completed by the addition of 3' A residues to the mRNA" /citation=[7] /codon_start=1 /transl_except=(pos:10404,aa:TERM) /transl_table=2 /product="MTND3" /protein_id="AAB58950.1" /db_xref="GI:506832" /translation="MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPM SPARVPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSL AYEWLQKGLDWTE" variation 10191..13752 /note="deleted in Pearson marrow-pancreas syndrome" /citation=[12] tRNA 10405..10469 /product="tRNA-Arg" /note="codon recognized: CGA; NAR: 0197" /anticodon=(pos:10435..10437,aa:Arg) mRNA 10470..12137 /product="RNA 7" CDS 10470..10766 /note="NADH dehydrogenase subunit 4L" /citation=[7] /codon_start=1 /transl_table=2 /product="MTND4L" /protein_id="AAB58951.1" /db_xref="GI:337197" /translation="MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMA TLMTLNTHSLLANIVPIAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC" variation 10666..14855 /note="deleted in Pearson marrow-pancreas syndrome" /citation=[12] /replace="" CDS 10760..12137 /note="NADH dehydrogenase subunit 4; TAA stop codon is completed by the addition of 3' A residues to the mRNA" /citation=[7] /codon_start=1 /transl_except=(pos:12137,aa:TERM) /transl_table=2 /product="MTND4" /protein_id="AAB58952.1" /db_xref="GI:506833" /translation="MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQ INNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISL QISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPL LIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPK AHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSIC LRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNY ERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNIT LLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLN PDIITGFSS" variation 11233..13979 /note="deleted in Pearson marrow-pancreas syndrome" /citation=[12] /replace="" tRNA 12138..12206 /product="tRNA-His" /note="codon recognized: CAC; NAR: 0897" /anticodon=(pos:12168..12170,aa:His) tRNA 12207..12265 /product="tRNA-Ser" /note="codon recognized: AGC; NAR: 1656" /anticodon=(pos:12226..12228,aa:Ser) tRNA 12266..12336 /product="tRNA-Leu" /note="codon recognized: CUA; NAR: 1097" /anticodon=(pos:12298..12300,aa:Leu) mRNA 12337..>14148 /product="RNA 5" CDS 12337..14148 /note="NADH dehydrogenase subunit 5" /citation=[7] /codon_start=1 /transl_table=2 /product="MTND5" /protein_id="AAB58953.1" /db_xref="GI:2052366" /translation="MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTF IISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIME FSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYA RADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLL AAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTL TLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAF FKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSK DHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTL LNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLT NKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTI SQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT" CDS complement(14149..14673) /note="NADH dehydrogenase subunit 6" /citation=[8] /codon_start=1 /transl_table=2 /product="MTND6" /protein_id="AAB58954.1" /db_xref="GI:2052367" /translation="MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIIL NFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGL VLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTL FVGVYIVIEIARGN" tRNA complement(14674..14742) /product="tRNA-Glu" /note="NAR: 0697" /anticodon=(pos:14704..14706,aa:Glu) mRNA 14747..15887 /product="RNA 11" CDS 14747..15881 /note="TAA stop codon is completed by the addition of 3' A residues to the mRNA" /codon_start=1 /transl_except=(pos:15881,aa:TERM) /transl_table=2 /product="cytochrome b" /protein_id="AAB58955.1" /db_xref="GI:506835" /translation="MTPMRKINPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQ ITTGLFLAMHYSPDASTAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGL YYGSFLYSETWNIGIILLLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDL VQWIWGGYSVDSPTLTRFFTFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKI TFHPYYTIKDALGLLLFLLSLMTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLF AYTILRSVPNKLGGVLALLLSILILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLI LTWIGGQPVSYPFTIIGQVASVLYFTTILILMPTISLIENKMLK" variation 15855 /note="g in wt; a in some HeLa cells" /citation=[9] variation 15880 /note="g in wt; c in some HeLa cells" /citation=[9] tRNA 15888..15953 /product="tRNA-Thr" /note="codon recognized: ACA; NAR: 1797" /anticodon=(pos:15919..15921,aa:Thr) variation 15889 /note="a in wt; g in some HeLa cells" /citation=[9] variation 15919..15922 /note="tata in wt; ta in some HeLa cells" /citation=[9] variation 15920 /note="a in wt; g in some HeLa cells" /citation=[9] variation 15924 /note="t in wt; c in some HeLa cells" /citation=[9] variation 15935..15937 /note="ctt in wt; ct in some HeLa cells" /citation=[9] variation 15936 /note="t in wt; c or g in some HeLa cells" variation 15937 /note="t in wt; c in some HeLa cells" /citation=[9] variation 15938..15942 /note="tacaa in wt; ta in some HeLa cells" /citation=[9] variation 15938..15940 /note="tac in wt; tc in some HeLa cells" /citation=[9] tRNA complement(15955..16023) /product="tRNA-Pro" /note="NAR: 1597" /anticodon=(pos:15986..15988,aa:Pro) rep_origin 16104..16569 conflict 16124 /citation=[4] /replace="" D-loop 16158..16172 /note="D-loop termination signal" /citation=[4] ORIGIN 1 gatcacaggt ctatcaccct attaaccact cacgggagct ctccatgcat ttggtatttt 61 cgtctggggg gtatgcacgc gatagcattg cgagacgctg gagccggagc accctatgtc 121 gcagtatctg tctttgattc ctgcctcatc ctattattta tcgcacctac gttcaatatt 181 acaggcgaac atacttacta aagtgtgtta attaattaat gcttgtagga cataataata 241 acaattgaat gtctgcacag ccactttcca cacagacatc ataacaaaaa atttccacca 301 aaccccccct cccccgcttc tggccacagc acttaaacac atctctgcca aaccccaaaa 361 acaaagaacc ctaacaccag cctaaccaga tttcaaattt tatcttttgg cggtatgcac 421 ttttaacagt caccccccaa ctaacacatt attttcccct cccactccca tactactaat 481 ctcatcaata caacccccgc ccatcctacc cagcacacac acaccgctgc taaccccata 541 ccccgaacca accaaacccc aaagacaccc cccacagttt atgtagctta cctcctcaaa 601 gcaatacact gaaaatgttt agacgggctc acatcacccc ataaacaaat aggtttggtc 661 ctagcctttc tattagctct tagtaagatt acacatgcaa gcatccccgt tccagtgagt 721 tcaccctcta aatcaccacg atcaaaaggg acaagcatca agcacgcagc aatgcagctc 781 aaaacgctta gcctagccac acccccacgg gaaacagcag tgattaacct ttagcaataa 841 acgaaagttt aactaagcta tactaacccc agggttggtc aatttcgtgc cagccaccgc 901 ggtcacacga ttaacccaag tcaatagaag ccggcgtaaa gagtgtttta gatcaccccc 961 tccccaataa agctaaaact cacctgagtt gtaaaaaact ccagttgaca caaaatagac 1021 tacgaaagtg gctttaacat atctgaacac acaatagcta agacccaaac tgggattaga 1081 taccccacta tgcttagccc taaacctcaa cagttaaatc aacaaaactg ctcgccagaa 1141 cactacgagc cacagcttaa aactcaaagg acctggcggt gcttcatatc cctctagagg 1201 agcctgttct gtaatcgata aaccccgatc aacctcacca cctcttgctc agcctatata 1261 ccgccatctt cagcaaaccc tgatgaaggc tacaaagtaa gcgcaagtac ccacgtaaag 1321 acgttaggtc aaggtgtagc ccatgaggtg gcaagaaatg ggctacattt tctaccccag 1381 aaaactacga tagcccttat gaaacttaag ggtcgaaggt ggatttagca gtaaactaag 1441 agtagagtgc ttagttgaac agggccctga agcgcgtaca caccgcccgt caccctcctc 1501 aagtatactt caaaggacat ttaactaaaa cccctacgca tttatataga ggagacaagt 1561 cgtaacatgg taagtgtact ggaaagtgca cttggacgaa ccagagtgta gcttaacaca 1621 aagcacccaa cttacactta ggagatttca acttaacttg accgctctga gctaaaccta 1681 gccccaaacc cactccacct tactaccaga caaccttagc caaaccattt acccaaataa 1741 agtataggcg atagaaattg aaacctggcg caatagatat agtaccgcaa gggaaagatg 1801 aaaaattata accaagcata atatagcaag gactaacccc tataccttct gcataatgaa 1861 ttaactagaa ataactttgc aaggagagcc aaagctaaga cccccgaaac cagacgagct 1921 acctaagaac agctaaaaga gcacacccgt ctatgtagca aaatagtggg aagatttata 1981 ggtagaggcg acaaacctac cgagcctggt gatagctggt tgtccaagat agaatcttag 2041 ttcaacttta aatttgccca cagaaccctc taaatcccct tgtaaattta actgttagtc 2101 caaagaggaa cagctctttg gacactagga aaaaaccttg tagagagagt aaaaaattta 2161 acacccatag taggcctaaa agcagccacc aattaagaaa gcgttcaagc tcaacaccca 2221 ctacctaaaa aatcccaaac atataactga actcctcaca cccaattgga ccaatctatc 2281 accctataga agaactaatg ttagtataag taacatgaaa acattctcct ccgcataagc 2341 ctgcgtcaga ttaaaacact gaactgacaa ttaacagccc aatatctaca atcaaccaac 2401 aagtcattat taccctcact gtcaacccaa cacaggcatg ctcataagga aaggttaaaa 2461 aaagtaaaag gaactcggca aatcttaccc cgcctgttta ccaaaaacat cacctctagc 2521 atcaccagta ttagaggcac cgcctgccca gtgacacatg tttaacggcc gcggtaccct 2581 aaccgtgcaa aggtagcata atcacttgtt ccttaaatag ggacctgtat gaatggctcc 2641 acgagggttc agctgtctct tacttttaac cagtgaaatt gacctgcccg tgaagaggcg 2701 ggcataacac agcaagacga gaagacccta tggagcttta atttattaat gcaaacagta 2761 cctaacaaac ccacaggtcc taaactacca aacctgcatt aaaaatttcg gttggggcga 2821 cctcggagca gaacccaacc tccgagcagt acatgctaag acttcaccag tcaaagcgaa 2881 ctactatact caattgatcc aataacttga ccaacggaac aagttaccct agggataaca 2941 gcgcaatcct attctagagt ccatatcaac aatagggttt acgacctcga tgttggatca 3001 ggacatcccg atggtgcagc cgctattaaa ggttcgtttg ttcaacgatt aaagtcctac 3061 gtgatctgag ttcagaccgg agtaatccag gtcggtttct atctaccttc aaattcctcc 3121 ctgtacgaaa ggacaagaga aataaggcct acttcacaaa gcgccttccc ccgtaaatga 3181 tatcatctca acttagtatt atacccacac ccacccaaga acagggtttg ttaagatggc 3241 agagcccggt aatcgcataa aacttaaaac tttacagtca gaggttcaat tcctcttctt 3301 aacaacatac ccatggccaa cctcctactc ctcattgtac ccattctaat cgcaatggca 3361 ttcctaatgc ttaccgaacg aaaaattcta ggctatatac aactacgcaa aggccccaac 3421 gttgtaggcc cctacgggct actacaaccc ttcgctgacg ccataaaact cttcaccaaa 3481 gagcccctaa aacccgccac atctaccatc accctctaca tcaccgcccc gaccttagct 3541 ctcaccatcg ctcttctact atgaaccccc ctccccatac ccaaccccct ggtcaacctc 3601 aacctaggcc tcctatttat tctagccacc tctagcctag ccgtttactc aatcctctga 3661 tcagggtgag catcaaactc aaactacgcc ctgatcggcg cactgcgagc agtagcccaa 3721 acaatctcat atgaagtcac cctagccatc attctactat caacattact aataagtggc 3781 tcctttaacc tctccaccct tatcacaaca caagaacacc tctgattact cctgccatca 3841 tgacccttgg ccataatatg atttatctcc acactagcag agaccaaccg aacccccttc 3901 gaccttgccg aaggggagtc cgaactagtc tcaggcttca acatcgaata cgccgcaggc 3961 cccttcgccc tattcttcat agccgaatac acaaacatta ttataataaa caccctcacc 4021 actacaatct tcctaggaac aacatatgac gcactctccc ctgaactcta cacaacatat 4081 tttgtcacca agaccctact tctaacctcc ctgttcttat gaattcgaac agcatacccc 4141 cgattccgct acgaccaact catacacctc ctatgaaaaa acttcctacc actcacccta 4201 gcattactta tatgatatgt ctccataccc attacaatct ccagcattcc ccctcaaacc 4261 taagaaatat gtctgataaa agagttactt tgatagagta aataatagga gcttaaaccc 4321 ccttatttct aggactatga gaatcgaacc catccctgag aatccaaaat tctccgtgcc 4381 acctatcaca ccccatccta aagtaaggtc agctaaataa gctatcgggc ccataccccg 4441 aaaatgttgg ttataccctt cccgtactaa ttaatcccct ggcccaaccc gtcatctact 4501 ctaccatctt tgcaggcaca ctcatcacag cgctaagctc gcactgattt tttacctgag 4561 taggcctaga aataaacatg ctagctttta ttccagttct aaccaaaaaa ataaaccctc 4621 gttccacaga agctgccatc aagtatttcc tcacgcaagc aaccgcatcc ataatccttc 4681 taatagctat cctcttcaac aatatactct ccggacaatg aaccataacc aatactacca 4741 atcaatactc atcattaata atcataatag ctatagcaat aaaactagga atagccccct 4801 ttcacttctg agtcccagag gttacccaag gcacccctct gacatccggc ctgcttcttc 4861 tcacatgaca aaaactagcc cccatctcaa tcatatacca aatctctccc tcactaaacg 4921 taagccttct cctcactctc tcaatcttat ccatcatagc aggcagttga ggtggattaa 4981 accagaccca gctacgcaaa atcttagcat actcctcaat tacccacata ggatgaataa 5041 tagcagttct accgtacaac cctaacataa ccattcttaa tttaactatt tatattatcc 5101 taactactac cgcattccta ctactcaact taaactccag caccacgacc ctactactat 5161 ctcgcacctg aaacaagcta acatgactaa cacccttaat tccatccacc ctcctctccc 5221 taggaggcct gcccccgcta accggctttt tgcccaaatg ggccattatc gaagaattca 5281 caaaaaacaa tagcctcatc atccccacca tcatagccac catcaccctc cttaacctct 5341 acttctacct acgcctaatc tactccacct caatcacact actccccata tctaacaacg 5401 taaaaataaa atgacagttt gaacatacaa aacccacccc attcctcccc acactcatcg 5461 cccttaccac gctactccta cctatctccc cttttatact aataatctta tagaaattta 5521 ggttaaatac agaccaagag ccttcaaagc cctcagtaag ttgcaatact taatttctgt 5581 aacagctaag gactgcaaaa ccccactctg catcaactga acgcaaatca gccactttaa 5641 ttaagctaag cccttactag accaatggga cttaaaccca caaacactta gttaacagct 5701 aagcacccta atcaactggc ttcaatctac ttctcccgcc gccgggaaaa aaggcgggag 5761 aagccccggc aggtttgaag ctgcttcttc gaatttgcaa ttcaatatga aaatcacctc 5821 ggagctggta aaaagaggcc taacccctgt ctttagattt acagtccaat gcttcactca 5881 gccattttac ctcaccccca ctgatgttcg ccgaccgttg actattctct acaaaccaca 5941 aagacattgg aacactatac ctattattcg gcgcatgagc tggagtccta ggcacagctc 6001 taagcctcct tattcgagcc gagctgggcc agccaggcaa ccttctaggt aacgaccaca 6061 tctacaacgt tatcgtcaca gcccatgcat ttgtaataat cttcttcata gtaataccca 6121 tcataatcgg aggctttggc aactgactag ttcccctaat aatcggtgcc cccgatatgg 6181 cgtttccccg cataaacaac ataagcttct gactcttacc tccctctctc ctactcctgc 6241 tcgcatctgc tatagtggag gccggagcag gaacaggttg aacagtctac cctcccttag 6301 cagggaacta ctcccaccct ggagcctccg tagacctaac catcttctcc ttacacctag 6361 caggtgtctc ctctatctta ggggccatca atttcatcac aacaattatc aatataaaac 6421 cccctgccat aacccaatac caaacgcccc tcttcgtctg atccgtccta atcacagcag 6481 tcctacttct cctatctctc ccagtcctag ctgctggcat cactatacta ctaacagacc 6541 gcaacctcaa caccaccttc ttcgaccccg ccggaggagg agaccccatt ctataccaac 6601 acctattctg atttttcggt caccctgaag tttatattct tatcctacca ggcttcggaa 6661 taatctccca tattgtaact tactactccg gaaaaaaaga accatttgga tacataggta 6721 tggtctgagc tatgatatca attggcttcc tagggtttat cgtgtgagca caccatatat 6781 ttacagtagg aatagacgta gacacacgag catatttcac ctccgctacc ataatcatcg 6841 ctatccccac cggcgtcaaa gtatttagct gactcgccac actccacgga agcaatatga 6901 aatgatctgc tgcagtgctc tgagccctag gattcatctt tcttttcacc gtaggtggcc 6961 tgactggcat tgtattagca aactcatcac tagacatcgt actacacgac acgtactacg 7021 ttgtagccca cttccactat gtcctatcaa taggagctgt atttgccatc ataggaggct 7081 tcattcactg atttccccta ttctcaggct acaccctaga ccaaacctac gccaaaatcc 7141 atttcactat catattcatc ggcgtaaatc taactttctt cccacaacac tttctcggcc 7201 tatccggaat gccccgacgt tactcggact accccgatgc atacaccaca tgaaacatcc 7261 tatcatctgt aggctcattc atttctctaa cagcagtaat attaataatt ttcatgattt 7321 gagaagcctt cgcttcgaag cgaaaagtcc taatagtaga agaaccctcc ataaacctgg 7381 agtgactata tggatgcccc ccaccctacc acacattcga agaacccgta tacataaaat 7441 ctagacaaaa aaggaaggaa tcgaaccccc caaagctggt ttcaagccaa ccccatggcc 7501 tccatgactt tttcaaaaag gtattagaaa aaccatttca taactttgtc aaagttaaat 7561 tataggctaa atcctatata tcttaatggc acatgcagcg caagtaggtc tacaagacgc 7621 tacttcccct atcatagaag agcttatcac ctttcatgat cacgccctca taatcatttt 7681 ccttatctgc ttcctagtcc tgtatgccct tttcctaaca ctcacaacaa aactaactaa 7741 tactaacatc tcagacgctc aggaaataga aaccgtctga actatcctgc ccgccatcat 7801 cctagtcctc atcgccctcc catccctacg catcctttac ataacagacg aggtcaacga 7861 tccctccctt accatcaaat caattggcca ccaatggtac tgaacctacg agtacaccga 7921 ctacggcgga ctaatcttca actcctacat acttccccca ttattcctag aaccaggcga 7981 cctgcgactc cttgacgttg acaatcgagt agtactcccg attgaagccc ccattcgtat 8041 aataattaca tcacaagacg tcttgcactc atgagctgtc cccacattag gcttaaaaac 8101 agatgcaatt cccggacgtc taaaccaaac cactttcacc gctacacgac cgggggtata 8161 ctacggtcaa tgctctgaaa tctgtggagc aaaccacagt ttcatgccca tcgtcctaga 8221 attaattccc ctaaaaatct ttgaaatagg gcccgtattt accctatagc accccctcta 8281 ccccctctag agcccactgt aaagctaact tagcattaac cttttaagtt aaagattaag 8341 agaaccaaca cctctttaca gtgaaatgcc ccaactaaat actaccgtat ggcccaccat 8401 aattaccccc atactcctta cactattcct catcacccaa ctaaaaatat taaacacaaa 8461 ctaccaccta cctccctcac caaagcccat aaaaataaaa aattataaca aaccctgaga 8521 accaaaatga acgaaaatct gttcgcttca ttcattgccc ccacaatcct aggcctaccc 8581 gccgcagtac tgatcattct atttccccct ctattgatcc ccacctccaa atatctcatc 8641 aacaaccgac taatcaccac ccaacaatga ctaatcaaac taacctcaaa acaaatgata 8701 accatacaca acactaaagg acgaacctga tctcttatac tagtatcctt aatcattttt 8761 attgccacaa ctaacctcct cggactcctg cctcactcat ttacaccaac cacccaacta 8821 tctataaacc tagccatggc catcccctta tgagcgggca cagtgattat aggctttcgc 8881 tctaagatta aaaatgccct agcccacttc ttaccacaag gcacacctac accccttatc 8941 cccatactag ttattatcga aaccatcagc ctactcattc aaccaatagc cctggccgta 9001 cgcctaaccg ctaacattac tgcaggccac ctactcatgc acctaattgg aagcgccacc 9061 ctagcaatat caaccattaa ccttccctct acacttatca tcttcacaat tctaattcta 9121 ctgactatcc tagaaatcgc tgtcgcctta atccaagcct acgttttcac acttctagta 9181 agcctctacc tgcacgacaa cacataatga cccaccaatc acatgcctat catatagtaa 9241 aacccagccc atgaccccta acaggggccc tctcagccct cctaatgacc tccggcctag 9301 ccatgtgatt tcacttccac tccataacgc tcctcatact aggcctacta accaacacac 9361 taaccatata ccaatgatgg cgcgatgtaa cacgagaaag cacataccaa ggccaccaca 9421 caccacctgt ccaaaaaggc cttcgatacg ggataatcct atttattacc tcagaagttt 9481 ttttcttcgc aggatttttc tgagcctttt accactccag cctagcccct accccccaat 9541 taggagggca ctggccccca acaggcatca ccccgctaaa tcccctagaa gtcccactcc 9601 taaacacatc cgtattactc gcatcaggag tatcaatcac ctgagctcac catagtctaa 9661 tagaaaacaa ccgaaaccaa ataattcaag cactgcttat tacaatttta ctgggtctct 9721 attttaccct cctacaagcc tcagagtact tcgagtctcc cttcaccatt tccgacggca 9781 tctacggctc aacatttttt gtagccacag gcttccacgg acttcacgtc attattggct 9841 caactttcct cactatctgc ttcatccgcc aactaatatt tcactttaca tccaaacatc 9901 actttggctt cgaagccgcc gcctgatact ggcattttgt agatgtggtt tgactatttc 9961 tgtatgtctc catctattga tgagggtctt actcttttag tataaatagt accgttaact 10021 tccaattaac tagttttgac aacattcaaa aaagagtaat aaacttcgcc ttaattttaa 10081 taatcaacac cctcctagcc ttactactaa taattattac attttgacta ccacaactca 10141 acggctacat agaaaaatcc accccttacg agtgcggctt cgaccctata tcccccgccc 10201 gcgtcccttt ctccataaaa ttcttcttag tagctattac cttcttatta tttgatctag 10261 aaattgccct ccttttaccc ctaccatgag ccctacaaac aactaacctg ccactaatag 10321 ttatgtcatc cctcttatta atcatcatcc tagccctaag tctggcctat gagtgactac 10381 aaaaaggatt agactgaacc gaattggtat atagtttaaa caaaacgaat gatttcgact 10441 cattaaatta tgataatcat atttaccaaa tgcccctcat ttacataaat attatactag 10501 catttaccat ctcacttcta ggaatactag tatatcgctc acacctcata tcctccctac 10561 tatgcctaga aggaataata ctatcgctgt tcattatagc tactctcata accctcaaca 10621 cccactccct cttagccaat attgtgccta ttgccatact agtctttgcc gcctgcgaag 10681 cagcggtggg cctagcccta ctagtctcaa tctccaacac atatggccta gactacgtac 10741 ataacctaaa cctactccaa tgctaaaact aatcgtccca acaattatat tactaccact 10801 gacatgactt tccaaaaaac acataatttg aatcaacaca accacccaca gcctaattat 10861 tagcatcatc cctctactat tttttaacca aatcaacaac aacctattta gctgttcccc 10921 aaccttttcc tccgaccccc taacaacccc cctcctaata ctaactacct gactcctacc 10981 cctcacaatc atggcaagcc aacgccactt atccagtgaa ccactatcac gaaaaaaact 11041 ctacctctct atactaatct ccctacaaat ctccttaatt ataacattca cagccacaga 11101 actaatcata ttttatatct tcttcgaaac cacacttatc cccaccttgg ctatcatcac 11161 ccgatgaggc aaccagccag aacgcctgaa cgcaggcaca tacttcctat tctacaccct 11221 agtaggctcc cttcccctac tcatcgcact aatttacact cacaacaccc taggctcact 11281 aaacattcta ctactcactc tcactgccca agaactatca aactcctgag ccaataactt 11341 aatatgacta gcttacacaa tagcttttat agtaaagata cctctttacg gactccactt 11401 atgactccct aaagcccatg tcgaagcccc catcgctggg tcaatagtac ttgccgcagt 11461 actcttaaaa ctaggcggct atggtataat acgcctcaca ctcattctca accccctgac 11521 aaaacacata gcctacccct tccttgtact atccctatga ggcataatta taacaagctc 11581 catctgccta cgacaaacag acctaaaatc gctcattgca tactcttcaa tcagccacat 11641 agccctcgta gtaacagcca ttctcatcca aaccccctga agcttcaccg gcgcagtcat 11701 tctcataatc gcccacgggc ttacatcctc attactattc tgcctagcaa actcaaacta 11761 cgaacgcact cacagtcgca tcataatcct ctctcaagga cttcaaactc tactcccact 11821 aatagctttt tgatgacttc tagcaagcct cgctaacctc gccttacccc ccactattaa 11881 cctactggga gaactctctg tgctagtaac cacgttctcc tgatcaaata tcactctcct 11941 acttacagga ctcaacatac tagtcacagc cctatactcc ctctacatat ttaccacaac 12001 acaatggggc tcactcaccc accacattaa caacataaaa ccctcattca cacgagaaaa 12061 caccctcatg ttcatacacc tatcccccat tctcctccta tccctcaacc ccgacatcat 12121 taccgggttt tcctcttgta aatatagttt aaccaaaaca tcagattgtg aatctgacaa 12181 cagaggctta cgacccctta tttaccgaga aagctcacaa gaactgctaa ctcatgcccc 12241 catgtctaac aacatggctt tctcaacttt taaaggataa cagctatcca ttggtcttag 12301 gccccaaaaa ttttggtgca actccaaata aaagtaataa ccatgcacac tactataacc 12361 accctaaccc tgacttccct aattcccccc atccttacca ccctcgttaa ccctaacaaa 12421 aaaaactcat acccccatta tgtaaaatcc attgtcgcat ccacctttat tatcagtctc 12481 ttccccacaa caatattcat gtgcctagac caagaagtta ttatctcgaa ctgacactga 12541 gccacaaccc aaacaaccca gctctcccta agcttcaaac tagactactt ctccataata 12601 ttcatccctg tagcattgtt cgttacatgg tccatcatag aattctcact gtgatatata 12661 aactcagacc caaacattaa tcagttcttc aaatatctac tcatcttcct aattaccata 12721 ctaatcttag ttaccgctaa caacctattc caactgttca tcggctgaga gggcgtagga 12781 attatatcct tcttgctcat cagttgatga tacgcccgag cagatgccaa cacagcagcc 12841 attcaagcaa tcctatacaa ccgtatcggc gatatcggtt tcatcctcgc cttagcatga 12901 tttatcctac actccaactc atgagaccca caacaaatag cccttctaaa cgctaatcca 12961 agcctcaccc cactactagg cctcctccta gcagcagcag gcaaatcagc ccaattaggt 13021 ctccacccct gactcccctc agccatagaa ggccccaccc cagtctcagc cctactccac 13081 tcaagcacta tagttgtagc aggaatcttc ttactcatcc gcttccaccc cctagcagaa 13141 aatagcccac taatccaaac tctaacacta tgcttaggcg ctatcaccac tctgttcgca 13201 gcagtctgcg cccttacaca aaatgacatc aaaaaaatcg tagccttctc cacttcaagt 13261 caactaggac tcataatagt tacaatcggc atcaaccaac cacacctagc attcctgcac 13321 atctgtaccc acgccttctt caaagccata ctatttatgt gctccgggtc catcatccac 13381 aaccttaaca atgaacaaga tattcgaaaa ataggaggac tactcaaaac catacctctc 13441 acttcaacct ccctcaccat tggcagccta gcattagcag gaataccttt cctcacaggt 13501 ttctactcca aagaccacat catcgaaacc gcaaacatat catacacaaa cgcctgagcc 13561 ctatctatta ctctcatcgc tacctccctg acaagcgcct atagcactcg aataattctt 13621 ctcaccctaa caggtcaacc tcgcttcccc acccttacta acattaacga aaataacccc 13681 accctactaa accccattaa acgcctggca gccggaagcc tattcgcagg atttctcatt 13741 actaacaaca tttcccccgc atcccccttc caaacaacaa tccccctcta cctaaaactc 13801 acagccctcg ctgtcacttt cctaggactt ctaacagccc tagacctcaa ctacctaacc 13861 aacaaactta aaataaaatc cccactatgc acattttatt tctccaacat actcggattc 13921 taccctagca tcacacaccg cacaatcccc tatctaggcc ttcttacgag ccaaaacctg 13981 cccctactcc tcctagacct aacctgacta gaaaagctat tacctaaaac aatttcacag 14041 caccaaatct ccacctccat catcacctca acccaaaaag gcataattaa actttacttc 14101 ctctctttct tcttcccact catcctaacc ctactcctaa tcacataacc tattcccccg 14161 agcaatctca attacaatat atacaccaac aaacaatgtt caaccagtaa ctactactaa 14221 tcaacgccca taatcataca aagcccccgc accaatagga tcctcccgaa tcaaccctga 14281 cccctctcct tcataaatta ttcagcttcc tacactatta aagtttacca caaccaccac 14341 cccatcatac tctttcaccc acagcaccaa tcctacctcc atcgctaacc ccactaaaac 14401 actcaccaag acctcaaccc ctgaccccca tgcctcagga tactcctcaa tagccatcgc 14461 tgtagtatat ccaaagacaa ccatcattcc ccctaaataa attaaaaaaa ctattaaacc 14521 catataacct cccccaaaat tcagaataat aacacacccg accacaccgc taacaatcaa 14581 tactaaaccc ccataaatag gagaaggctt agaagaaaac cccacaaacc ccattactaa 14641 acccacactc aacagaaaca aagcatacat cattattctc gcacggacta caaccacgac 14701 caatgatatg aaaaaccatc gttgtatttc aactacaaga acaccaatga ccccaatacg 14761 caaaattaac cccctaataa aattaattaa ccactcattc atcgacctcc ccaccccatc 14821 caacatctcc gcatgatgaa acttcggctc actccttggc gcctgcctga tcctccaaat 14881 caccacagga ctattcctag ccatgcacta ctcaccagac gcctcaaccg ccttttcatc 14941 aatcgcccac atcactcgag acgtaaatta tggctgaatc atccgctacc ttcacgccaa 15001 tggcgcctca atattcttta tctgcctctt cctacacatc gggcgaggcc tatattacgg 15061 atcatttctc tactcagaaa cctgaaacat cggcattatc ctcctgcttg caactatagc 15121 aacagccttc ataggctatg tcctcccgtg aggccaaata tcattctgag gggccacagt 15181 aattacaaac ttactatccg ccatcccata cattgggaca gacctagttc aatgaatctg 15241 aggaggctac tcagtagaca gtcccaccct cacacgattc tttacctttc acttcatctt 15301 gcccttcatt attgcagccc tagcaacact ccacctccta ttcttgcacg aaacgggatc 15361 aaacaacccc ctaggaatca cctcccattc cgataaaatc accttccacc cttactacac 15421 aatcaaagac gccctcggct tacttctctt ccttctctcc ttaatgacat taacactatt 15481 ctcaccagac ctcctaggcg acccagacaa ttatacccta gccaacccct taaacacccc 15541 tccccacatc aagcccgaat gatatttcct attcgcctac acaattctcc gatccgtccc 15601 taacaaacta ggaggcgtcc ttgccctatt actatccatc ctcatcctag caataatccc 15661 catcctccat atatccaaac aacaaagcat aatatttcgc ccactaagcc aatcacttta 15721 ttgactccta gccgcagacc tcctcattct aacctgaatc ggaggacaac cagtaagcta 15781 cccttttacc atcattggac aagtagcatc cgtactatac ttcacaacaa tcctaatcct 15841 aataccaact atctccctaa ttgaaaacaa aatactcaaa tgggcctgtc cttgtagtat 15901 aaactaatac accagtcttg taaaccggag atgaaaacct ttttccaagg acaaatcaga 15961 gaaaaagtct ttaactccac cattagcacc caaagctaag attctaattt aaactattct 16021 ctgttctttc atggggaagc agatttgggt accacccaag tattgactca cccatcaaca 16081 accgctatgt atttcgtaca ttactgccag ccaccatgaa tattgtacgg taccataaat 16141 acttgaccac ctgtagtaca taaaaaccca atccacatca aaaccccctc cccatgctta 16201 caagcaagta cagcaatcaa ccctcaacta tcacacatca actgcaactc caaagccacc 16261 cctcacccac taggatacca acaaacctac ccacccttaa cagtacatag tacataaagc 16321 catttaccgt acatagcaca ttacagtcaa atcccttctc gtccccatgg atgacccccc 16381 tcagataggg gtcccttgac caccatcctc cgtgaaatca atatcccgca caagagtgct 16441 actctcctcg ctccgggccc ataacacttg ggggtagcta aagtgaactg tatccgacat 16501 ctggttccta cttcagggtc ataaagccta aatagcccac acgttcccct taaataagac 16561 atcacgatg //